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KMID : 1120320230090040137
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Osteoporosis and Sarcopenia
2023 Volume.9 No. 4 p.137 ~ p.141
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Effect of romosozumab in premenopausal women with severe osteoporosis and anorexia nervosa
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Kazuki Fujimoto
Narumi Maki
Daisuke Hashiba
Toshifumi Maeyama
Ryosuke Nakagawa
Hajime Arai
Seiji Ohtori
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Abstract
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Objectives: This study aims to investigate the effects of romosozumab on bone mineral density (BMD) and bone metabolism.
Methods: In this retrospective case series, romosozumab was administered to 5 premenopausal female patients with osteoporosis and anorexia nervosa with fragility fractures. BMD and bone turnover marker changes were investigated at 6 months and 1 year after administering romosozumab.
Results: BMD increased and high-turnover bone metabolism decreased 6 months and 1 year after administering romosozumab.
Conclusions: Romosozumab is useful for treating osteoporosis in patients with anorexia nervosa.
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KEYWORD
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Anorexia nervosa, Secondary osteoporosis, Anti-sclerostin antibody, Bone metabolism
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